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In recent years plastination has begun to revolutionize the way in which human and veterinary gross anatomy can be presented to students around the world. The plastination methodology consists of slowly replacing tissue fluid with a polymer, under vacuum. The more popular plastination technique is based on a very common polymer, silicone. This MOOC is aimed at introducing those who are interested in plastination into the S10 plastination technique. The course is divided in four main modules and an introduction one attending the main steps of the technique: specimen preparation and fixation, dehydration, impregnation and curing.